Supplements to Support (and Avoid) During GLP-1 Weight Loss

GLP-1 medications can be life-changing tools for weight loss, helping regulate appetite and improve metabolic health. But with reduced food intake and changes in digestion, it’s important to pay attention not just to what you eat, but also to the nutrients your body might be missing.

Ideally, most of your vitamins and minerals should come from whole foods. Fresh fruits, vegetables, lean proteins, whole grains, and healthy fats will always be the foundation of good health. But when you’re eating less—or struggling to hit protein and nutrient goals—supplements can play an important role in filling gaps and protecting your whole health.

Just as important: not all supplements are helpful. Some may be unnecessary, poorly absorbed, or even counterproductive when you’re using GLP-1s.

Here’s a complete guide to what we recommend including—and what you may want to avoid.

​✅ Supplements to Consider During GLP-1 Therapy

1. High-Quality Multivitamin
​​
Why it helps: Appetite suppression often means fewer opportunities to get key micronutrients. A multivitamin ensures you’re covering the basics like B vitamins, zinc, and magnesium to support energy and immunity.

2. Protein Supplements (Shakes or Meal Replacements)

Why it helps: Protein is critical for preserving lean mass while losing weight. GLP-1 patients often struggle to get enough protein from whole foods alone. A shake, bar, or structured high-protein meal replacement can make it much easier to hit your daily target (~0.7–1.0g per pound of body weight).

3. Fiber

Why it helps: GLP-1s can slow digestion, and reduced food volume often lowers fiber intake. Supplementing with fiber supports gut health, prevents constipation, and helps with fullness.

4. Electrolytes

Why it helps: Weight loss changes hydration and mineral balance. Low electrolytes can lead to fatigue, headaches, or muscle cramps. Supplementing with a sugar-free electrolyte powder or tablet helps maintain hydration and energy.

5. Vitamin D + Omega-3s

Why they help: Vitamin D deficiency is common and can affect immunity, mood, and bone health. Omega-3s reduce inflammation, support heart health, and may improve satiety signaling. Together they’re a powerful combo for whole-body health.

6. Essential Amino Acids (EAAs)

Why they help: EAAs provide the building blocks for muscle repair and recovery, especially important when total protein intake is low. They can help prevent muscle breakdown during calorie restriction.

7. Creatine Monohydrate

Why it helps: Creatine supports muscle strength, energy production, and even cognitive function. It can help maintain strength and exercise performance while on a calorie deficit. A simple daily dose of 3–5g is safe and well-researched.

8. Probiotics

Why they help: GLP-1s can slow digestion, leading to changes in bowel habits. Probiotics support gut balance, digestion, and may even improve overall metabolic health.

​❌ Supplements to Be Cautious With or Avoid

Not all supplements are a good fit for GLP-1 patients. Some can interfere with digestion, duplicate what you’re already getting, or create unnecessary risks.

• Fat-burning/thermogenic products: These often contain caffeine or stimulants that can increase heart rate, anxiety, and GI upset. GLP-1s already improve satiety and metabolic function—these products add little benefit and more risk.
• Excessive fiber supplements: While moderate fiber is helpful, too much can worsen bloating, gas, and slowed digestion (especially since GLP-1s already delay gastric emptying).
• High-dose fat-soluble vitamins (A, D, E, K): Over-supplementation can be harmful because these vitamins store in fat tissue. Always check levels before supplementing heavily.
• Herbal blends marketed for “weight loss” or “detox”: Many lack evidence, may interact with medications, and can strain the liver or kidneys.
• Duplicate protein or amino acid products: More is not always better. Over-supplementing protein or amino acids isn’t dangerous for most, but it’s unnecessary if you’re already meeting your daily target.

Final Thoughts

Supplements can’t replace a healthy lifestyle, but they can help fill important gaps during GLP-1 therapy—especially when appetite suppression makes it harder to meet your body’s needs. Focus on protein, essential nutrients, muscle support, gut health, and hydration.

At the same time, be cautious with unnecessary or poorly researched products, and remember: always check with your medical provider before starting new supplements, especially if you’re on prescription medications.

The best approach is a foundation of nutrient-rich whole foods, supported by targeted supplements that keep your body strong, energized, and balanced throughout your weight loss journey.

👉 Want help choosing the right plan and finding high-quality options to support your journey? Explore our Medical Weight Loss Programs
 and visit our Supplements Page
.